Ian Papautsky, PhD
Richard and Loan Hill Professor
Building & Room:
COMRB 5053 (lab: COMRB 5020)
851 S Morgan St, SEO 218
Office Phone Voice:
Co-Director, NSF Center for Advanced Design & Manufacturing of Integrated Microfluidics
The Papautsky lab is focused on innovating blood analysis technologies, using microfluidics and sensing, for precision and point-of-care medicine. The Papautsky lab uses electrochemical analytical methods for point-of-care determination of trace metals (namely Mn, Pb, Zn) in blood. Both anodic and cathodic stripping voltammetry methods are used, in conjunction with miniature sensors that have a form-factor of a USB stick, and capable of rapid measurements from a single drop of blood (from a lancet puncture), which is a more ideal approach for pediatric patients. The Papautsky lab also pioneered the inertial microfluidics technology for label-free isolation and analysis of rare cells. Inertial microfluidics relies on interaction of hydrodynamic forces acting on flowing cells and leads to lateral migration across streamlines into specific cross-sectional positions depending on their size (Lab Chip, 13: 1121, 2013; Technology, 4: 88, 2016). The approach shows tremendous potential for high-throughput cell separations in biomedicine (Analyst, 142: 2558, 2017; Scientific Reports, 8: 9411, 2018). The Papautsky lab has recently focused on capture and molecular profile analysis of circulating tumor cells (CTCs) and circulating tumor microemboli (CTM), whose molecular profile can provide a “cancer census” that is more holistic representation of disease state and active pathophysiology.
J. Zhou, A. Kulasinghe, A. Bogseth, K. O’Byrne, C. Punyadeera, and I. Papautsky, “Isolation of circulating tumor cells in non-small-cell-lung-cancer (NSCLC) patients using a multi-flow microfluidic channel”, Microsystems & Nanoengineering, 2019, doi: 10.1038/s41378-019-0045-6.
A. Kulasinghe, J. Zhou, L. Kenny, I. Papautsky, and C. Punyadeera, “Capture of circulating tumour cell clusters using straight microfluidic chip,” Cancers, 2019, 11(1), 89; doi: 10.3390/cancers11010089.
P. Mukherjee, X. Wang, J. Zhou, and I. Papautsky, “Single stream inertial focusing in low aspect-ratio triangular microchannels,” Lab Chip, 2019, 19, 147-157.
J. Zhou, C. Tu, Y. Liang, B. Huang, Y. Fang, X. Liang, I. Papautsky and X. Ye, “Isolation of cells from whole blood using shear-induced diffusion,” Scientific Reports, 2018, 8, 9411 doi:10.1038/s41598-018-27779-2
Service to Community
2017 Workshop Chair, The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2017), Savannah, GA, 22-26 October 2017.
2016 Workshop Organizer, The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2016), Dublin, Ireland, 9-13 October 2016.
2016-present Technical Program Committee, The International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS)
2014 Conference Committee, The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS 2014), San Antonio, TX, October 26-30, 2014.
2008-present Conference Organizing Committee, International Conference on SPIE Microfluidics, BioMEMS, and Medical Microsystems, San Francisco, CA
2004-2007 Conference Chair, International Conference on SPIE Microfluidics, BioMEMS, and Medical Microsystems, San Jose, CA.
2018, Distinguished Established Researcher Award, College of Medicine, University of Illinois at Chicago
2016, Distinguished Engineering Researcher Award, College of Engineering and Applied Sciences, University of Cincinnati
2013, William H. Middendorf Research Excellence Award, Department of Electrical and Computer Engineering, University of Cincinnati
2007, Ohio Bioscience 30 in Their 30s, The State of Ohio
1999 Ph.D. in Bioengineering, University of Utah, Salt Lake City, Utah
1995 B.S. in Biomedical Engineering, Boston University, Boston, Massachusetts
Fellow, American Institute for Medical and Biological Engineering (AIMBE)
Fellow, Royal Society of Chemistry (RSC)
Senior Member, IEEE Engineering in Medicine and Biology Society (EMBS)