Photo of Alsberg, Eben

Eben Alsberg, PhD

Richard and Loan Hill Professor of Bioengineering

Department of Mechanical and Industrial Engineering, Department of Orthopaedics

Department of Pharmacology

Contact

Building & Room:

7005A COMRB

Address:

909 South Wolcott Avenue, MC 563, Chicago, IL 60612

About

Office Location: 7005 COMRB

Lab Location: 7120 COMRB

Lab Website: http://engineering.case.edu/ebme/alsberg

Google Scholar: https://scholar.google.com/citations?user=thaz6kcAAAAJ&hl=en

Research Interest: Prof. Alsberg’s research is focused on innovative biomaterials, microenvironments and bioactive factor delivery vehicles for functional tissue engineering, regenerative medicine and disease therapeutics; control of stem cell fate decision; precise temporal and spatial presentation of signals to regulate cell function; mechanotransduction and the influence of mechanics on cell behavior and tissue formation; organoids and organogenesis; therapeutic angiogenesis; and cell-cell interactions.

Selected Publications

Jeon O, Lee YB, Jeong H, Lee SJ, Wells D, Alsberg E: Individual cell-only bioink and photocurable supporting medium for 3D printing and generation of engineering tissues with complex geometries. Materials Horizons (in press, 2019).

McDermott AM, Herberg S, Mason DE, Collins JM, Pearson HB, Dawahare JH, Tang R, Patwa AN, Grinstaff MW, Kelly DJ, Alsberg E*, Boerckel JD*: Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration. Science Translational Medicine, 11(495), 2019. *Co-corresponding authors.

Nguyen MK, Huynh CT, Gilewski A, Wilner S, Maier K, Kwon N, Levy M*, Alsberg E*: Covalently tethering siRNA to hydrogels for localized, controlled release and gene silencing. Science Advances (in press, 2019). *Co-corresponding authors.

Herberg S, McDermott AM, Dang PN, Alt DS, Tang R, Dawahare JH, Varghai D, Shin J-Y, McMillan A, Dikina AD, He F, Lee Y, Cheng Y, Umemori K, Wong PC, Park H, Boerckel JD*, Alsberg E*: Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair. Science Advances (in press, 2019). *Co-corresponding authors.

Jeon O, Lee YB, Hinton TJ, Feinberg AW, Alsberg E: Cryopreserved cell-laden alginate microgel bioink for 3D bioprinting of living tissues. Materials Today Chemistry (in press, 2019).

Huynh CT, Liu F, Cheng Y, Coughlin KA, Alsberg E: Thiol-epoxy “click” chemistry to engineer cytocompatible PEG-based hydrogel for siRNA-mediated osteogenesis of hMSCs. ACS Applied Materials and Interfaces, 10(31): 25936-25942, 2018.

Nguyen MK, Jeon O, Dang PN, Huynh CT, Varghai D, Riazi H, McMillan A, Herberg S, Alsberg E: RNA interfering molecule delivery from in situ forming biodegradable hydrogels for enhancement of bone formation in rat calvarial bone defects. Acta Biomaterialia, 75:105-114, 2018

Jeon O, Lee K, Alsberg E: Spatial Micropatterning of Growth Factors in 3D Hydrogels for Location–Specific Regulation of Cellular Behaviors. Small, 14(25):e1800579, 2018.

Herberg S, Varghai D, Cheng Y, Dikina AD, Dang PN, Rolle MW, Alsberg E: High-density human mesenchymal stem cell rings with spatiotemporally-controlled morphogen presentation as building blocks for engineering bone diaphyseal tissue. Nanotheranostics, 2(2):128-143, 2018.

Seo J, Shin JY, Leijten J, Jeon O, Bal ÖA, Rouwkema J, Li Y, Shin S, Hajiali H, Alsberg E*, Khademhosseini E*: Interconnectable Dynamic Compression Bioreactors for Combinatorial Screening of Cell Mechanobiology in Three-dimensions. ACS Applied Materials & Interfaces, 10(16): 13293-13303, 2018. *Co-corresponding authors.

McMillan A, Nguyen MK, Gonzalez-Fernandez T, Ge P, Yu X, Murphy WL, Kelly DJ, Alsberg E: Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering. Biomaterials, 161: 240-255, 2018.

Dikina AD, Alt DS, Herberg S, McMillan A, Strobel HA, Zheng Z, Cao M, Lai BP, Jeon O, Petsinger VI, Cotton CU, Rolle MW, Alsberg E: A modular strategy to engineer complex tissues and organs. Advanced Science, 5(5): 1700402, 2018.

Jeon O, Shin JY, Marks R, Hopkins M, Kim TH, Park H, Alsberg E: Highly elastic and tough interpenetrating polymer network-structured hybrid hydrogels for cyclic mechanical loading-enhanced tissue engineering. Chemistry of Materials, 29(19): 8425-8432, 2017.

Dang PN, Herberg S, Varghai D, Riazi H, Varghai D, McMillan A, Awadallah A, Phillips LM, Jeon O, Nguyen MK, Dwivedi N, Yu X, Murphy WL, Alsberg E: Endochondral ossification in critical-sized bone defects via readily implantable scaffold-free stem cell constructs. Stem Cells Translational Medicine, 6(7): 1644-1659, 2017.

Education

Postdoc, Harvard Medical School, 2005
Ph.D., Biomedical Engineering, University of Michigan, 2002
M.S.E., Biomedical Engineering, University of Michigan, 1998
M.S.E., Mechanical Engineering, University of Michigan, 1998
B.S.E., Biomedical Engineering, Duke University, 1994
B.S.E., Mechanical Engineering and Materials Science, Duke University, 1994