David K. Wood, PhD
Assistant Professor, Department of Biomedical Engineering, University of Minnesota
Title: Engineered Microsystems as Advanced In Vitro Models of Pathology
Abstract: Our laboratory is focused on the development of engineered in vitro model systems that bridge the gap between existing in vitro culture systems and animal models to study mechanisms of pathology and to develop new therapeutics. We leverage microtechnology to control cell-cell interactions, tissue architecture, and physical and chemical cues at physiologic scales to recapitulate in vivo microenvironments while allowing control over critical parameters. In this talk, I will present our work in sickle cell disease, for which we have developed an in vitro platform to study sickle blood flow under physiologic levels of shear, pressure, and oxygen. I will also present our work in cancer metastasis, for which we have developed a microfluidic platform to study the processes of tumor cell extravasation, invasion and colonization of a metastatic site. I will discuss our recent results on the role of tissue resident macrophages in tumor cell extravasation.